The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals, 9th Edition

Huw Golledge (Editor), Claire Richardson (Editor)

ISBN: 9781119555247

March 2024 

Wiley-Blackwell 

1040 Pages

DESCRIPTION

The UFAW Handbook on The Care and Management of Laboratory and Other Research Animals

The latest edition of the seminal reference on the care and management of laboratory and research animals

The newly revised ninth edition of The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals delivers an up-to-date and authoritative exploration on worldwide developments, current thinking, and best practices in the field of laboratory animal welfare science and technology.

The gold standard in laboratory and captive animal care and management references, this latest edition continues the series’ tradition of excellence by including brand-new chapters on ethical review, the care of aged animals, and fresh guidance on the care of mole rats, corvids, zebrafish, and decapods.

The book offers introductory chapters covering a variety of areas of laboratory animal use, as well as chapters on the management and care of over 30 different taxa of animals commonly utilised in scientific procedures and research around the world. It also provides:

• A thorough introduction to the design of animal experiments, laboratory animal genetics, and the phenotyping of genetically modified mice

• Comprehensive explorations of animal welfare assessment and the ethical review process

• Practical discussions of legislation and oversight of the conduct of research using animals from a global perspective

• In-depth examinations of the planning, design, and construction of efficient animal facilities, special housing arrangements, and nutrition, feeding, and animal welfare

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals Ninth Edition is essential for laboratory animal scientists, veterinarians, animal care staff, animal care regulatory authorities, legislators, and professionals working in animal welfare non-governmental organizations.

TABLE OF CONTENTS

List of contributors vii

Foreword xi

1 Introduction 1

Part 1 Implementing the Three Rs in research using animals 3

2 The Three Rs 5

3 The design of animal experiments 23

4 An introduction to laboratory animal genetics 40

5 Phenotyping of genetically modified mice 54

6 Brief introduction to welfare assessment: a ‘toolbox’ of techniques 64

7 Welfare and ‘best practice’ in field studies of wildlife 84

8 Legislation and oversight of the conduct of research using animals: a global overview 101

9 Planning, design and construction of the modern animal facility 122

10 Environmental enrichment: animal welfare and scientific validity 137

11 Special housing arrangements 150

12 Transportation of laboratory animals 171

13 Nutrition, feeding and animal welfare 191

14 Attaining competence in the care of animals used in research 220

15 The use of positive reinforcement training techniques to enhance the care and welfare oflaboratory and research animals 236

16 3Rs considerations when using ageing animals in science 251

17 Euthanasia and other fates for laboratory animals 268

18 Ethics review of animal research 281

Appendix 294

Part 2 Species kept in the laboratory 297

Mammals 299

19 The laboratory opossum 301

20 Tree Shrews 324

Rodentia and Lagomorpha 340

21 The laboratory mouse: Biology, behaviour, enrichment and welfare: first principles and realsolutions for laboratory mice 340

22 The laboratory rat 379

23 The laboratory gerbil 400

24 The Syrian hamster 419

25 Voles 430

26 The naked mole-rat (Heterocephalus glaber) 442

Appendix A 459

27 The guinea pig 465

28 The laboratory rabbit 484

Carnivora 506

29 The ferret 506

30 The laboratory dog 518

31 The domestic cat 546

Ungulates 570

32 Pigs and minipigs 570

33 Cattle 596

34 Sheep and goats 609

35 The Horse 628

Non-Human Primates 662

36 The mouse lemurs 662

37 Marmosets and tamarins 683

38 Capuchin monkeys 707

39 Old world monkeys 721

Birds 739

40 The domestic fowl 741

41 The Japanese quail 762

42 The zebra finch 787

43 Pigeons and doves 807

44 The European starling 824

45 Corvids 839

Reptiles and Amphibia 853

46 Terrestrial reptiles: lizards, snakes and tortoises 855

47 An amphibian ‘laboratory model’, Xenopus 881

Fish 905

48 Fishes 907

49 Zebrafish 933

Cephalopoda 957

50 Cephalopoda 959

Decapoda 991

51 Decapod crustaceans 993

Index 1012

ABOUT THE AUTHOR

Huw Golledge is Chief Executive Officer and Scientific Director at the Universities Federation for Animal Welfare (UFAW), UK. He has served as a member of the UK Animals in Science Committee which advises the government on the use of animals in research.

Claire Richardson has over twenty years of experience in the field of laboratory animal welfare and has worked as a laboratory animal veterinarian as well as an animal welfare scientist. She is a member of the editorial team at the Universities Federation for Animal Welfare (UFAW), UK.