assessment toxicology studies

    higher magnification

    situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents

    images at higher magnification

Abbreviations

Introduction

Goals

Developmental Stages

Materials and Methods

Acknowledgments

References

Chapter 1. Skin and Mammary Gland

Abstract

Introduction

Skin (Histologic Anatomy and Development)

Histologic Anatomy of the Skin

Postnatal Development of the Skin

Mammary Gland

References

Chapter 2. Musculoskeletal System

Abstract

Introduction

Skeletal Muscle

Bone

References

Chapter 3. Nervous System

Abstract

Introduction

Brain

Spinal Cord

Peripheral Nerves

References

Chapter 4. Respiratory System

Abstract

Introduction

Embryologic Development of the Respiratory Tract

Nasal Cavity

Larynx and Trachea

Bronchi, Bronchioles, and Terminal Bronchioles

Lung

References

Chapter 5. Gastrointestinal Tract

Abstract

Introduction

Control of Postnatal Development

Tongue

Esophagus

Stomach

Small Intestine

Large Intestine

References

Chapter 6. Liver, Exocrine Pancreas, and Salivary Glands

Abstract

Introduction

Liver

Exocrine Pancreas

Salivary Glands

References

Chapter 7. Female Reproductive System

Abstract

Introduction

Ovary

Oviduct

Uterus

Cervix

Vagina

References

Chapter 8. Male Reproductive System

Abstract

Introduction

Testes

Epididymis

Vas Deferens

Seminal Vesicles

Prostate Gland

References

Chapter 9. The Endocrine System

Abstract

Introduction

Pituitary Gland

Pancreatic Endocrine Tissue

Thyroid Gland

Parathyroid Gland

Adrenal Gland

References

Chapter 10. Immune System

Abstract

Introduction

Bone Marrow

Thymus

Spleen

Lymph Nodes

Mucosa-Associated Lymphoid Tissue (MALT)

Summary

References

Chapter 11. Hematopoietic System

Abstract

Hematopoiesis

References

Chapter 12. The Eye and Harderian Gland

Abstract

Introduction

Embryological Development of the Eye

Postnatal Development of the Eye

References

Chapter 13. Urinary System

Abstract

Introduction

Kidney

Lower Urinary Tract

References

Chapter 14. Cardiovascular System

Abstract

Introduction

Transition From Fetal to Postnatal Circulation

Heart

Great Vessels

References

Index

Author Information

George Parker 

Dr. Parker received the Doctor of Veterinary Medicine (DVM) degree from the Auburn University College of Veterinary Medicine, completed a veterinary pathology residency at the Armed Forces Institute of Pathology, and received a PhD degree in immunology from Rutgers University. He is a diplomate of the American College of Veterinary Pathologists as well as the American Board of Toxicology, and a Fellow of the International Academy of Toxicologic Pathology. He has more than 30 years of experience as a toxicologic pathologist, and has served as study pathologist on several hundred drug and chemical safety studies that were performed in a number of laboratory animal species, most commonly rats. He has published numerous book chapters and peer-reviewed journal articles that have been focused primarily on toxicologic pathology. In his current position of Vice President of Global Pathology at WIL Research, he provides scientific and professional guidance to 20 full-time and 10 consultant pathologists in the U.S. and Europe. His major scientific interests are in the areas of immunopathology and toxicologic pathology of juvenile animals.

Catherine Picut

Dr. Catherine Picut is a graduate of the University of Pennsylvania School of Veterinary Medicine, completed a residency program in veterinary pathology at Cornell University, and received a law degree from Yale University. She is a diplomate of the American College of Veterinary Pathologists and the American Board of Toxicology as well as a registered patent attorney and quality assurance professional (RQAP-GLP). She has 22 years of experience providing research pathology services on studies

involving the safety evaluation of new drugs, biologics, medical devices and chemicals. She has published numerous articles in peer-reviewed scientific journals and has been author or co-author on numerous book chapters. Her special research interests are in reproductive and juvenile toxicology. Currently she is a senior pathologist at the Hillsborough, North Carolina site of WIL Research.