In no other species of animal has such a wealth of experimental data been utilized for scientific pursuits. Now in its Second Edition, this Four Volume Set is dedicated to the understanding of the mouse and its role in scientific research. This valuable compendium serves as a standard reference source of information for students embarking on scientific careers, specialists in laboratory animal science, technicians in both animal care and research, and the broad scientific community.

This set is also sold individually and covers History, Wild Mice, and Genetics; Diseases; Normative Biology, Husbandry, and Models; and Immunology.

Volume 1: History, Wild Mice, and Genetics
KEY FEATURES:
• A primer for scientists new to the field of mouse research
• Information about the history, biology and genomics of the laboratory mouse (Mus musculus)
• Mouse origins and relationships covered in chapters on history, evolutionary taxonomy and wild mice
• Mouse genetics and genomics discussed in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome
• Use of the mouse as a model system for basic biomedical research described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation

Volume 2: Diseases
KEY FEATURES:
• New format by discussing specific disease causing microorganisms versus the format used in the first edition which discussed infectious diseases affecting specific organs and tissues
• Consists of 26 chapters subdivided into RNA viruses and DNA viruses, mycotic, and parasitic infections.
• Provides updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens
• Offers information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter

Volume 3: Normative Biology, Husbandry, and Models
KEY FEATURES:
• Encompasses 23 chapters with a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research.
• Includes chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry.
• Discusses management, nutrition, gnotobiotics and disease surveillance
• Provides analysis of the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases

Volume 4: Immunology
KEY FEATURES:
• A complete new addition to this series, dedicated to mouse immunology including both the innate and adaptive immune systems
• Based on the mouse as a choice model when studying immunity in man-arguably more is known about the immune system in mice than any other species except man
• Chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells

Volume I History, Wild Mice, and Genetics

1. Building a Better Mouse: One Hundred Years of Genetics and Biology
Herbert C. Morse III

2. Systematics of the genus Mus
Priscilla K. Tucker

3. The Secret World of Wild Mice
Grant R. Singleton and Charles J. Krebs

4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types
Melissa L. Berry and Carol Cutler Linder

5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide
Janan T. Eppig

6. The Mouse Genome
Mark D. Adams

7. Gene Mapping
Muriel T. Davisson

8. Genetic Monitoring
Richard R. Fox, Michael V. Wiles, and Petko M. Petkov

9. Cytogenetics
Muriel T. Davisson and Mary Ann Handel

10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man
M.H. Kaufman

11. Gamete and Embryo Manipulation
K.C. Kent Lloyd

12. Chemical Mutagenesis in Mice
Martin Hrabé de Angelis, Dian Michel, Sibylle Wagner, Sonja Becker and Johannes Beckers

13. Gene-Specific Mutagenesis
K.C. Kent Lloyd

14. Gene Transfer Studies Using Mouse Models
Robert G. Pergolizzi and Ronald G. Crystal

15. Mouse and Human Pluripotent Stem Cells
Leslie F. Lock

16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics
Lucia F. Jorge-Nebert, Sandrine Derkenne and Daniel W. Nebert


Volume II Diseases

Viral Diseases

DNA Viruses

1. Mouse Cytomegalovirus and other Herpesviruses
Geoffrey R. Shellam, Alec J. Redwood, Lee M. Smith and Shelley Gorman

2. Mouse Adenoviruses
Katherine R. Spindler, Martin L. Moore, Angela N. Cauthen

3. Mousepox
R. Mark L. Buller and Frank Fenner

4. Parvoviruses
Robert O. Jacoby and Lisa Ball-Goodrich

5. Polyoma Viruses
Thomas L. Benjamin


RNA Viruses

6. Mouse Hepatitis Virus
Stephen W. Barthold and Abigail L. Smith

7. Lymphocytic Choriomeningitis Virus
Stephen W. Barthold and Abigail L. Smith

8. Lactate Dehydrogenase-Elevating Virus
Jean-Paul Coutelier and Margo A. Brinton

9. Reoviridae
Richard L. Ward, Monica M. McNeal, Mary B. Faron and Anthony L. Farone

10. Retroelements in the Mouse
Herbert C. Morse III

11. Sendai Virus and Pneumonia Virus of Mice (PVM)
David G. Brownstein

12. Cardioviruses: Encephalomyocarditis Virus and Theiler's Mouse Encephalomyelitis Virus
Howard L. Lipton, A.S. Manoj Kumar, and Shannon Hertzler


Bacterial Diseases

13. Chlamydial Diseases
Robert G. Rank

14. Clostridial Species
Kimberly S. Waggie

15. Enterobacteriaceae, Pseudomonas aeruginosa, and Streptobacillus moniliformis
Hilda Holcombe and David B. Schauer

16. Aerobic Gram-positive Organisms
Cynthia Besch-Williford and Craig L. Franklin

17. Helicobacter Infections in Mice
James G. Fox and Mark T. Whary

18. Mycoplasma pulmonis, Other Mouse Mycoplasmas, and Cilia-Associated Respiratory Bacillus
Trenton R. Schoeb

19. Pasteurellaceae
Werner Nicklas


Mycotic and Parasitic Diseases

20. Fungal Diseases in Laboratory Mice
Virginia L. Godfrey

21. Protozoa
Katherine Wasson

22. Helminth Parasites of Laboratory Mice
Kathleen R. Pritchett

23. Anthropods
David G. Baker


Miscellaneous Diseases

24. The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathology
Robert D. Cardiff, Robert J. Munn, and Jose J. Galvez

25. Spontaneous Diseases in Commonly Used Mouse Strains
Cory Brayton

26. Zoonoses and Other Human Health Hazards
Christian E. Newcomer and James G. Fox


Volume III Normative Biology, Husbandry, and Models

Normative Biology

1. Gross Anatomy
Vladimír Komárek

2. Mouse Physiology
Robert F. Hoyt, Jr., James V. Hawkins, Mark B. St Claire and Mary B. Kennett

3. Reproductive Biology of the Laboratory Mouse
Kate Pritchett and Robert Taft

4. Endocrinology: Bone as a target tissue for hormonal regulation
Krista M. Delahunty and Wesley G. Beamer

5. Hematology of the Laboratory Mouse
Nancy E. Everds

6. Clinical Chemistry of the Laboratory Mouse
Fred W. Quimby and Richard H. Luong


Management, Techniques, and Husbandry

7. Gnotobiotics
Richard J. Rahija

8. Management and Design: Breeding Facilities
William J. White

9. Design and Management of Research Facilities for Mice
Neil S. Lipman

10. Nutrition
Graham Tobin, Karla A. Stevens and Robert J. Russell

11. Health Delivery and Quality Assurance Programs for Mice
Diane J. Gaertner, Glen Otto and Margaret Batchelder

12. Environmental and Equipment Monitoring
J. David Small and Rick Deitrich

13. Biomethodology and Surgical Techniques
Alison M. Hayward, Laura B. Lemke, Erin C. Bridgeford, Elizabeth J. Theve, Courtnye N. Jackson, Terrie L. Cunliffe-Beamer, Robert P. Marini

14. In Vivo Whole-Body Imaging of the Laboratory Mouse
Simon R. Cherry


Use of Mice in Biomedical Research

15. Behavioral Testing
Douglas Wahlsten and John C. Crabbe

16. Cardiovascular Disease: Mouse Models of Atherosclerosis
Nobuyo Maeda, Raymond C. Givens and Robert L. Reddick

17. Convulsive Disorders
Mariana T. Todorova and Thomas N. Seyfried

18. Eye Research
Richard S. Smith, Patsy M. Nishina, John P. Sundberg, Johann Zwaan, and Simon W.M. John

19. Genetic Analysis of Rodent Obesity and Diabetes
Sally Chiu, Janis S. Fisler, and Craig H. Warden

20. Mouse Models in Aging Research
Kevin Flurkey, Joanne M. Currer, and D.E. Harrison

21. Mouse Models of Inherited Human Neurodegenerative Disease
Karl Herrup

22. Mouse Skin Ectodermal Organs
Maksim V. Plikus, John P. Sundberg, and Cheng-Ming Chuong

23. Quality Control Testing of Biologicals
William R. Shek


Volume IV Immunology

Molecular and Cellular Immunology of the Mouse: An Overview
Fred W. Quimby and David D. Chaplin

1. The Molecular Basis of Lymphoid Architecture in the Mouse
Carola G. Vinuesa and Matthew C. Cook

2. The Biology of Toll-like Receptors in Mice
Osamu Takeuchi and Shizuo Akira

3. Genomic Organization of the Mouse Major Histocompatibility Complex
Attila Kumánovics

4. Some Biological Features of Dendritic Cells in the Mouse
Kang Liu, Anna Charalambous and Ralph M. Steinman

5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff

6. Mouse Natural Killer Cells: Function and Activation
Francesco Colucci

7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
Bin Liu and Ke Shuai

8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
Lakshmi R. Nagarajan and Yoji Shimizu

9. Mouse Models of Negative Selection
Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist

10. Peripheral Tolerance of T Cells in the Mouse
Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao

11. The Genetics of Mouse Models of Systemic Lupus
Srividya Subramanian and Edward K. Wakeland

12. Inhibitory Receptors and Autoimmunity in the Mouse
Menna R. Clatworthy and Kenneth G.C. Smith

13. Mouse Models of Immunodeficiency
B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert

14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu

15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Javier Mestas and Christopher C.W. Hughes