The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee, Second Edition

March 24, 2015 by CRC Press
Reference - 390 Pages
ISBN 9781482201109

Features

• Includes new material on international regulations regarding animal subject research and requirements for an ethics panel review, outside collaborations, and interinstitutional memorandums of understanding
• Contains a new chapter on semiannual program reviews, semiannual inspections, and postapproval monitoring
• Updates information on the protocol submission process, electronic protocol management systems, and records management
• Addresses essential elements of the protocol form and how to complete it
• Delves deeply into bioethics to explore how IACUCs can ensure that each proposal to use animals in research includes an ethical review (harm-benefit analysis)
• Includes a chapter on how to survive a USDA inspection and AAALAC site visit

Summary

Maintaining its user-friendly approach, The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee, Second Edition is a handy guide for members of the laboratory animal community looking for a concise, descriptive introduction to what an IACUC is all about and how it operates. The book covers training programs and discusses professional certifications for IACUC administrative and animal care staff. It provides pointers to principal investigators, discusses interactions between IACUCs and other compliance panels, and addresses occupational health and safety programs and the role they play in the overall animal care and use program.

This new edition of a bestseller contains new information on international regulations regarding animal subject research and the requirements for an ethics panel review. It discusses outside collaborations, interinstitutional memorandums of understanding, and the differences in regulations between countries. The book also includes a new chapter exploring semiannual program reviews, semiannual inspections, and postapproval monitoring. The contributors provide updated information on the protocol submission process, electronic protocol management systems, and records management—including the essential elements of the protocol form and how to complete it.

The book also delves deeply into bioethics. It discusses how IACUCs can ensure that each proposal to use animals in research includes an ethical review with a harm–benefit analysis weighing the expected advancements in human and animal health against the potential harm inflicted to the animal. Also included is a chapter on how to survive a regulatory inspection or an accreditation site visit.

All interpretations of the regulations have been reviewed by staff at the NIH Office of Laboratory Animal Welfare (OLAW), the Animal Welfare Information Center (AWIC), and USDA APHIS/Animal Care (AC) for consistency and compliance with the PHS Policy and the USDA Animal Welfare Act Regulations (AWAR).

Table of Contents

Introduction to the IACUC: Its Purpose and Function; Cyndi Rosenblatt and Patrick Sharp
Role of the IACUC, Bioethics and Scientific Review, Essential Environment for IACUC Success; Jerry Collins
Institutional Policies, Guidelines, and Procedures; Mary Jo Shepherd
Protocol Processing: From Submission to Approval; Melinda S. Hollander
Elements of the Protocol Form: How to Complete and Review; Monte Matthews
Semiannual Program Evaluation, Facility Inspections, and Postapproval Monitoring: All Part of the Same Thing; Deborah A. Frolicher
IACUC Oversight of Training and Qualification in Animal Care and Use; Nicole Duffee
Navigating the Search for Alternatives; Mary W. Wood and Michael Kreger
The Relationship between the IACUC and Principal Investigators; Bill Yates
Interactions with Other Institutional Panels; William G. Greer
The IACUC and Laboratory Animal Resources; Stephen A. Felt and Sherril L. Green
International IACUCs and Outside Collaborations; Patrick Sharp
IACUCs from an Academic Perspective; Linda N. Brovarney
IACUC Issues in Industry; Marcy Brown and Jane Chambers
Perspectives of an IACUC Chair; Kathleen A. Murray
Perspectives of a Nonaffiliated/Outside Member; Mark S. Christensen
Managing a Proactive Progressive Animal Care and Use Program; Taylor Bennett and Andrew D. Cardon
Acronyms and Abbreviations
Appendices:
Forms, Templates and Notices
Resources for IACUC Information
Regulatory Agency Contact Information
Guidelines for Blood Sample Withdrawal
Volume Guidelines for Compound Administration
Sample IACUC Guideline
USDA Pain Categories

Editor(s) Bio

Whitney Petrie is an Institutional Animal Care and Use Committee (IACUC) specialist at the University of California, Davis, where she is responsible for protocol and amendment review, facility and laboratory inspections and the completion of various regulatory reports. She received a bachelor’s degree in biochemistry, summa cum laude, from the University of New Mexico in 1994. As an undergraduate, she worked in a laboratory within the Toxicology and Pharmacology Department where she researched skin cancer. She remained at the University of New Mexico until 2008, at which time she completed her PhD in biomedical sciences concentrating on cell biology within the Department of Molecular and Cellular Biology. She then moved to the University of California, Davis where as a postdoctoral fellow she researched breast cancer. Dr. Petrie also sits on various subcommittees within the IACUC. She is certified as an American Association for Laboratory Animal Science (AALAS)-registered laboratory animal technologist and a certified professional IACUC administrator.

Sonja L. Wallace is the training specialist in the Veterinary Service Center in the Department of Comparative Medicine at Stanford University, responsible for the development and implementation of animal care and use training programs for faculty and staff. Ms. Wallace received an AAS in animal health technology from Colorado Mountain College in 1981 and a BA in biological science from California State University East Bay in 2000. Ms. Wallace worked for over 20 years in pharmaceutical research as a veterinary surgical technician, cardiovascular researcher, toxicology biologist, training and compliance specialist, and IACUC manager. She also served for 5 years as the Associate Director of the Administrative Panel on Laboratory Animal Care in Stanford’s Research Compliance Office. Ms. Wallace is a Registered Veterinary Technician (RVT), AALAS-registered Laboratory Animal Technologist (RLATG), and Certified Professional IACUC Administrator (CPIA).