Key Features

• Offers an essential introduction to molecular genetics and the ''molecular'' aspects of human disease
• Teaches from the perspective of ''integrative systems biology,'' which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
• In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
• ''Traditional'' pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
• Explains the practice of ''molecular medicine'' and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
• Student web site hosts ''self-assessment'' questions; Professor web site hosts all figures from book
• Each chapter ends with Key Summary Points and Suggested Readings

Description

This streamlined ";essential"; version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

Table of Contents

PART I Essential Pathology - Mechanisms of Disease

Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation

John J. Lemasters, M.D., Ph.D.

Chapter 2 Acute and Chronic Inflammation

Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.

Chapter 3 Infection and Host Response

Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.

Chapter 4 Neoplasia

William B. Coleman, Ph.D., and Tara Rubinas, M.D.

PART II Concepts in Molecular Biology and Genetics

Chapter 5 Basic Concepts in Human Molecular Genetics

W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.

Chapter 6 The Human Genome: Implications for the Understanding of Human Disease

William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.

Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease

Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.

Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease

Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.

Chapter 9 The Human Proteome: Implications for the Understanding of Human Disease

Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin

Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease

M. Michael Barmada, Ph.D. and David C. Whitcomb

PART III Principles and Practice of Molecular Pathology

Chapter 11 Pathology: The Clinical Description of Human Disease

William K. Funkhouser, M.D., Ph.D.

Chapter 12 Molecular Pathogenesis: The Biological Basis of Human Disease

William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.

Chapter 13 Integration of Molecular and Cellular Pathogenesis

Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.

PART IV Molecular Pathology of Human Disease

Chapter 14 Molecular Basis of Cardiovascular Disease

Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu

Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases

Nigel S. Key, M.D., and Alice Ma, M.D.

Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases

Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.

Chapter 17 Molecular Basis of Diseases of Immunity

David O. Beenhouwer, Ph.D.

Chapter 18 Molecular Basis of Pulmonary Disease

Dani S. Zander, M.D., and Carol Farver, M.D.

Chapter

Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract

Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.

Chapter 20 Molecular Basis of Liver Disease

Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.

Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas

Markus M. Lerch, M.D.

Chapter 22 Molecular Basis of Diseases of the Endocrine System

Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.

Chapter 23 Molecular Basis of Gynecologic Diseases

Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.

Chapter 24 Molecular Pathogenesis of Diseases of the Kidney

Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.

Chapter 25 Molecular Basis of Prostate Disease

William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.

Chapter 26 Molecular Basis of Breast Disease

Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard

Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium

Chapter 27 Molecular Basis of Skin Disease

John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.

Chapter 28 Molecular Basis of Diseases of the Nervous System

Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.

PART V Practice of Molecular Medicine

Chapter 29 Molecular Diagnosis of Human Disease

Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.

Chapter 30 Molecular Assessment of Human Disease in the Clinical Laboratory

Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.

Chapter 31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.

Author Information

Edited by William B. Coleman, Associate Professor and Director of Graduate Studies Department of Pathology and Laboratory Medicine Curriculum in Toxicology Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, USA and Gregory J. Tsongalis, Associate Professor, Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH, USA