okvet [Medical Biochemistry, 2e

신간POD: 신간도서이나 출판사의 물류비 절감을 위해 주문시마다 제작하는 도서

POD도서의 특성상 책의 형태로 인쇄하고 제본한 결과물이 정상 출간된 도서에 비해 퀄리티가 떨어질 수 있습니다.

Authors: Antonio Blanco, Gustavo Blanco
Pages: 908
Published: March 23, 2022
Imprint: Academic Press
ISBN: 9780323915991

This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance.

Researchers and clinicians in biochemistry, molecular biology, and molecular medicine; medical faculty, and postdocs, medical students

Copyright
Dedication
Preface
Cover
Introduction
Chapter 1: Chemical composition of living beings
Abstract
Biogenic elements
Biological compounds
Summary
Further reading
Chapter 2: Water
Abstract
The water molecule is polar
Hydrogen bond
Water as solvent
Water as an electrolyte
Equilibrium constant
Equilibrium of water ionization
Acids and bases
The strength of acids and bases
pH
Buffers
Titration curve of acids and bases
Appendix
Summary
Further reading
Chapter 3: Proteins
Abstract
Proteins are macromolecules formed by amino acids
Amino acids
Peptides
Proteins
Collagen
Keratins
Hemoglobin
Heme
Globin
Hemoglobin derivatives
Abnormal hemoglobins
Blood plasma proteins
Main plasma proteins
Muscle proteins
Muscle contraction
Proteomics
Summary
Further reading
Chapter 4: Carbohydrates
Abstract
Monosaccharides
Disaccharides
Polysaccharides
Summary
Further reading
Chapter 5: Lipids
Abstract
Classification
Fatty acids
Essential fatty acids
Simple lipids
Complex lipids
Substances associated with lipids
Summary
Further reading
Chapter 6: Nucleic acids
Abstract
Nucleotides
Nucleic acids
Virus
Free nucleotides
Summary
Further reading
Chapter 7: Elements of thermodynamics and biochemical kinetics
Abstract
Thermodynamics
The cell as an open system
Chemical kinetics
Summary
Further reading
Chapter 8: Enzymes
Abstract
Enzymes are biological catalysts
Nomenclature and classification of enzymes
Chemical nature of enzymes
Metalloenzymes
Enzymatic catalysis
Active site
Zymogens
Genetic alterations that affect enzyme function
Enzyme distribution within the cell
Multienzyme systems
Determination of enzyme activity
Factors that modify enzyme activity
Enzyme inhibitors
Regulation of enzyme activity
Constitutive and inducible enzymes
Enzymatic processes in cascade
Isozymes
Determination of enzymes in the clinical laboratory
Summary
Further reading
Chapter 9: Biological oxidations: Bioenergetics
Abstract
The energy-rich intermediate ATP
Oxidation-reduction
Biological oxidations
Respiratory chain
Oxidative phosphorylation
Phosphorylation at substrate level
Other electron transport systems
Summary
Further reading
Chapter 10: Antioxidants
Abstract
Reactive species
Summary
Further reading
Chapter 11: Membranes
Abstract
Structure
Transport across membranes
Passive transport or facilitated diffusion
Active transport
Summary
Further reading
Chapter 12: Digestion—Absorption
Abstract
Saliva
Gastric secretion
Pancreatic juice
Intestinal mucosa
Bile
Summary of the digestive process
Absorption
Gastrointestinal microbiome
Summary
Further reading
Chapter 13: Metabolism
Abstract
Metabolic pathways
Metabolic studies
Regulation of metabolism
Summary
Further reading
Chapter 14: Carbohydrate metabolism
Abstract
Glucose uptake into cells
Glucose phosphorylation
Metabolic pathways for glucose
Metabolism of other hexoses
Biosynthesis of oligosaccharides in glycoproteins
Summary
Further reading
Chapter 15: Lipid metabolism
Abstract
Plasma lipoprotein metabolism
Fat metabolism
Fatty acid biosynthesis
Eicosanoid biosynthesis
Triacylglycerol biosynthesis
Phospholipid biosynthesis
Congenital disorders of complex lipid catabolism
Cholesterol metabolism
Cholesterol biosynthesis
Alterations of plasma lipids
Summary
Further reading
Chapter 16: Amino acid metabolism
Abstract
Essential AA
Amino acid catabolism
Metabolic pathways of ammonia
Other general mechanisms of amino acid metabolism
Metabolic pathways of AA
Summary
Further reading
Chapter 17: Heme metabolism
Abstract
Heme biosynthesis
Catabolism of heme
Summary
Further reading
Chapter 18: Purine and pyrimidine metabolism
Abstract
Purine biosynthesis
Purine salvage pathway
Purine catabolism
Uric acid
Gout
Pyrimidine biosynthesis
Pyrimidine catabolism
Di- and triphosphate nucleoside biosynthesis
Deoxyribonucleotide biosynthesis
Pharmacological approaches to purine and pyrimidine metabolism
Summary
Further reading
Chapter 19: Integration and regulation of metabolism
Abstract
Interconversion of carbohydrates, lipids, and amino acids
Metabolic regulation
Summary
Further reading
Chapter 20: Metabolism in some tissues
Abstract
Liver metabolism
Skeletal muscle metabolism
Heart metabolism
Adipose tissue metabolism
Nervous tissue metabolism
Summary
Further reading
Chapter 21: The genetic information (I)
Abstract
DNA replication
Transcription
Molecular biology
Summary
Further reading
Chapter 22: The genetic information (II)
Abstract
Protein biosynthesis
Mechanism of protein synthesis
Genetic mutations
Oncogenes
Epigenetics
Summary
Further reading
Chapter 23: Regulation of gene expression
Abstract
Gene regulation in eukaryotes
Gene regulation by noncoding RNAs
Small noncoding RNAs
Long noncoding RNAs
Riboswitches
Summary
Further reading
Chapter 24: Posttranslational protein modifications
Abstract
Protein folding
Pathologies caused by misfolded proteins
Posttranslational protein modifications
Summary
Further reading
Chapter 25: Biochemical basis of endocrinology (I) receptors and signal transduction
Abstract
Receptors
Signal transduction systems
Summary
Further reading
Chapter 26: Biochemical bases of endocrinology (II) hormones and other chemical intermediates
Abstract
Hormones
Endocrine glands and their hormones
Placental hormones
Thyroid hormones
Adrenal gland hormones
Pancreatic hormones
Gonadal hormones
Parathyroid gland hormones
Kidney hormones
Heart hormones
Gastrointestinal hormones
Pineal gland hormone
Eicosanoids
Growth factors
Nervous system chemical intermediaries (Neurotransmitters)
Summary
Further reading
Chapter 27: Vitamins
Abstract
Fat-soluble vitamins
Water-soluble vitamins
Summary
Further reading
Chapter 28: Water and acid-base balance
Abstract
Water distribution in the body
Water balance
Ionic composition of body fluids
Alterations of the water balance
H+ concentration in body fluids
Regulation of H+ concentration
Carbon dioxide transport
Regulatory systems
Respiratory regulation
Renal regulation
Regulation of intracellular pH
Acid-base balance disorders
H+ excretion regulation
Laboratory studies in acid-base disorders
Summary
Further reading
Chapter 29: Essential minerals
Abstract
Macrominerals
Trace elements
Summary
Further reading
Chapter 30: Molecular basis of immunity
Abstract
Immune system
Innate system
Adaptive system
Genetic diversity of immunoglobulins
Complement
Cellular immunity
Cytokines
Vaccines
Summary
Further reading
Chapter 31: Hemostasis
Abstract
Blood coagulation
Coagulation disorders
Summary
Further reading
Chapter 32: Cell death
Abstract
Apoptosis
Summary
Further reading
Index

Antonio Blanco

Dr. Antonio Blanco is an M.D. and Ph.D. at the National University of Cordoba, Argentina. He was Research Associate at The Johns Hopkins School of Medicine at Baltimore (US) for 4 years. He has been the Chairman of the Department of Biochemistry of the National University of Cordoba for 31 years and is currently Emeritus Professor of the National University of Cordoba, Argentina. He is also a member of several academic societies, including the National Academy of Sciences, and the National Academy of Physical and Natural Sciences of Argentina.

Affiliations and Expertise

Emeritus Professor, National University of Cordoba, Cordoba, Argentina

Gustavo Blanco

Dr. Gustavo Blanco is an M.D. and Ph.D. from the University of Cordoba, Argentina and currently a Professor at Kansas University Medical Center. Dr. Blanco’s research focuses on renal biology and reproductive biology, as well as regulation and function of Na,K-ATPase isozymes. He has published widely in such peer reviewed journals as the Journal of Medicinal Chemistry, Steroids, Experimental Cell Research, Molecules, Frontiers in Physiology, and the American Journal of Physiology.

Affiliations and Expertise

Professor and Kathleen M. Osborn Chair, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS United States